A predisposing effect of HLA class II genes in celiac disease by skewing the naive CD4+ T cell receptor repertoire
Proceedings of the National Academy of Sciences, Volume 123, Issue 26, June 2026. SignificanceHuman leukocyte antigen (HLA) genes can predispose to immune-mediated diseases via two mechanisms: a) altering selection of the T cell receptor (TCR) repertoire during T cell maturation or b) affecting presentation of disease-related epitopes …Continue Reading










