debian-13-“trixie”:-best-new-features

A roundup of the key features of the latest Debian 13 release. After almost two years of development, Debian 13 “Trixie” is now available to download and upgrade from Debian 12. This critical release brings few major updates including latest packages across modules, Linux Kernel 6.12 LTS, modern desktop environmentsContinue Reading

Reprogramming CRISPR–Cas enzymes for customized genome editing

Research Briefing Published: 02 February 2026 Nature Biotechnology (2026)Cite this article Subjects We developed Protein2PAM, an evolution-informed protein language model that predicts protospacer-adjacent motif (PAM) specificity of CRISPR–Cas enzymes. Using in silico mutagenesis and model-guided evolution, we generated Cas9 variants with broadened PAM compatibility and higher activity, enabling editing of genomic sites that were previouslyContinue Reading