Reprogramming CRISPR–Cas enzymes for customized genome editing

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Research Briefing Published: 02 February 2026 Nature Biotechnology (2026)Cite this article Subjects We developed Protein2PAM, an evolution-informed protein language model that predicts protospacer-adjacent motif (PAM) specificity of CRISPR–Cas enzymes. Using in silico mutagenesis and model-guided evolution, we generated Cas9 variants with broadened PAM compatibility and higher activity, enabling editing of genomic sites that were previouslyContinue Reading

Rolls-Royce’s New Electric SUV Prototype Spotted Undergoing Cold-weather Testing (Photos)

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Rolls-Royce’s new electric SUV prototype has been spotted undergoing cold-weather testing. Electric SUV will arrive as the brand’s second battery-electric vehicle, following the success of the Spectre Coupe. Spectre Coupe, the brand’s first EV, was Rolls-Royce’s best-selling car in 2025 after the Cullinan SUV. Electric Rolls-Royce SUV could rival the upcoming electric SUV models ofContinue Reading

elementary-os-8.1:-best-new-features

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The elementary OS 8.1 is now available to download and upgrade. If you are a fan of the most beautiful Linux distributions, elementary OS makes the cut. The latest from the team is elementary OS 8.1, which brings targeted improvements that enhance security, performance, and everyday workflows without overhauling theContinue Reading

schneider-electric-launches-ev-charging-system-delivering-up-to-720-kw-and-decentralized-architecture

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Schneider Electric has introduced Schneider StarCharge Fast 720, an EV charging system for commercial and industrial sites and fleet operators in Europe. The system delivers up to 720 kW and can charge up to 12 vehicles simultaneously, targeting higher-throughput charging as demand for eMobility grows. Schneider Electric reports 97% efficiencyContinue Reading

cyclic-materials-raises-$75-million-to-scale-rare-earth-magnet-recycling

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Cyclic Materials has closed a $75-million Series C equity round to scale its rare earth element recycling operations across the US and Europe and accelerate its Canada-based research and development footprint. The company says the funding will speed deployment of locally anchored recycling infrastructure for magnet-containing end-of-life scrap and magnetContinue Reading