Customizing CRISPR–Cas PAM specificity with protein language models

Collias, D. & Beisel, C. L. CRISPR technologies and the search for the PAM-free nuclease. Nat. Commun. 12, 555 (2021). Article  CAS  PubMed  PubMed Central  Google Scholar  Karvelis, T. et al. Rapid characterization of CRISPR–Cas9 protospacer adjacent motif sequence elements. Genome Biol. 16, 253 (2015). Article  PubMed  PubMed Central  Google Scholar  Gasiunas, G. et al.Continue Reading

why-4-engine-aircraft-could-go-back-into-production

Four-engine commercial jets like the legendary jumbo Boeing 747 and superjumbo Airbus A380 have largely been phased out in favor of more efficient twin-engine widebodies. Yet, there are some cases that suggest future demand for four-engine passenger aircraft could re-emerge, even if only in niche markets.Continue Reading

musk-says-spacex-has-acquired-xai

Musk previously merged xAI with the social platform X in a deal last March that valued the AI firm at $80 billion., Musk previously merged xAI with the social platform X in a deal last March that valued the AI firm at $80 billion., from Newsnation Read MoreContinue Reading

northern-graphite-and-obeikan-to-develop-battery-anode-material-plant-in-saudi-arabia

Canada-based Northern Graphite and Saudi industrial group Obeikan Investment have signed a financing agreement to jointly develop and operate a large-scale battery anode material (BAM) facility in Saudi Arabia through a joint venture company. The $200-million BAM facility will have an initial annual production capacity of 25,000 tonnes. Construction ofContinue Reading